It is revealed that they first met not long after the death of Nawaki, Tsunade's younger brother. It was revealed that Dan had a younger sister who was killed in the war. Seeing as Dan was just like her, Tsunade fell in love with him and the two soon began dating. As a sign of her affection, and in the hopes that this time it would help make his dreams come true, Tsunade gave him Hashirama's necklace.
Orochimaru approached Tsunade and offered to revive her younger brother and Dan if she agreed to heal his hands. Tsunade appeared to agree, but instead of healing Orochimaru's hands, she attempted to destroy them. She then told Orochimaru that she would never accept his offer. When Orochimaru arrived to the battlefield, he saw Tsunade in a deplorable condition with her body ripped apart, and commented that he had never seen her in such a bad shape. He ordered both Suigetsu and Karin to help Katsuyu heal Tsunade.
While Naruto might not have been an anime with romance as its main focus, many characters still ended up developing crushes, deep connections, and romantic relationships with their fellow ninjas. However, there were also many ninja pairs who had the potential to become an official couple but somehow didn't end up together by the end of the series. Whether their hearts ended up elsewhere or it just wasn't meant to be, we need to acknowledge all the ninja couples that were amazing in theory. Updated By Amanda Bruce On January 10, With the world of Naruto continuing into the next generation of Boruto , it's easy to continue speculating about fan favorite characters and pairings. Fans can still wonder "what if?
She is famed as the world's strongest kunoichi and its greatest medical-nin. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years. Tsunade is the granddaughter of Hashirama Senju and Mito Uzumaki. Hashirama doted on Tsunade when she was very young because she was his first grandchild, and found her deviance and her adoption of his own gambling habits highly amusing.